The first attempts to build Murcia Cathedral date back to the time of the Reconquista. On 2 February 1266 a great procession led by King Jaime I the Conqueror and the Bishop Fray Pedro Gallego, crossed the conquered city and headed towards the Aljama Mosque where a small chapel was established for saying mass, and the mosque was consecrated under the patronage of St Mary the Great.
Since 1291 it has served as the main Cathedral, when the Episcopal seat was moved from Cartagena to Murcia, making the most of the naves of the prayer room of the mosque for liturgical functions.